Effects of anticoagulants with Danshen on patency of Dacron microprostheses in animal experiments

Although the development of microsurgery has improved resurfacing complicated wounds with various flaps, it also leads to some problems. The elevation of some flaps, such as forearm skin flaps and posterior tibial artery flaps, satisfies one of two main arteries that supply blood to the extremities. However, some patients feel cold on the distal part of their extremities after operation. The best way to resolve this problem is to reconstruct the excised arteries. In some surgical procedures, flaps lack enough pedicle length to reach the wound, and harvesting autogenous saphenous veins is required to extend the length of the pedicle. However, this procedure is time consuming and involves another donor incision. To solve the problems mentioned above, vascular prostheses can be used as a substitute for vessel segments. Although large diameter vascular prostheses have been used clinically for more than 30 years with satisfactory patency rates (1), difficulty arises when a small diameter graft is required because of the potential for it to be occluded. Whether a graft remains patent depends on the formation of neointima and the epithelialization on the luminal surface of the graft,